Vitamin D Deficiency
Diseases and conditions cause by vitamin D deficiency:
· Osteoporosis is commonly caused by a lack of vitamin D, which greatly impairs calcium absorption.
· Sufficient vitamin D prevents prostate cancer, breast cancer, ovarian cancer, depression, colon cancer and schizophrenia.
· “Rickets” is the name of a bone-wasting disease caused by vitamin D deficiency.
· Vitamin D deficiency may exacerbate type 2 diabetes and impair insulin production in the pancreas.
· Obesity impairs vitamin D utilization in the body, meaning obese people need twice as much vitamin D.
· Vitamin D is used around the world to treat Psoriasis.
· Vitamin D deficiency causes schizophrenia.
· Seasonal Affective Disorder is caused by a melatonin imbalance initiated by lack of exposure to sunlight.
· Chronic vitamin D deficiency is often misdiagnosed as fibromyalgia because its symptoms are so similar: muscle weakness, aches and pains.
· Your risk of developing serious diseases like diabetes and cancer is reduced 50% – 80% through simple, sensible exposure to natural sunlight 2-3 times each week.
· Infants who receive vitamin D supplementation (5000 IU daily) have an 80% reduced risk of developing type 1 diabetes over the next twenty years.
Shocking Vitamin D deficiency statistics:
- 32% of doctors and med school students are vitamin D deficient.
- 40% of the U.S. population is vitamin D deficient.
- 42% of African American women of childbearing age are deficient in vitamin D.
- 48% of young girls (9-11 years old) are vitamin D deficient.
- Up to 60% of all hospital patients are vitamin D deficient.
- 76% of pregnant mothers are severely vitamin D deficient, causing widespread vitamin Deficiencies in their unborn children, which predisposes them to type 1 diabetes, arthritis, multiple sclerosis and schizophrenia later in life. 81% of the children born to these mothers were deficient.
- Up to 80% of nursing home patients are vitamin D deficient.
What you can do:
Sensible exposure to natural sunlight is the simplest, easiest and yet one of the most important strategies for improving your health. I urge you to read the book, “The UV Advantage” by Dr. Michael Holick to get the full story on natural sunlight. You can find this book at most local bookstores or through BN.com, Amazon.com, etc. Note: This is not a paid endorsement or an affiliate link. I recommend it because of its great importance in preventing chronic disease and enhancing health without drugs or surgery.
This may be the single most important book on health you ever read.
If more people understood this information, we could drastically reduce the rates of chronic disease in this country and around the world. Sunlight exposure is truly one of the most powerful healing therapies in the world, far surpassing the best efforts of today’s so-called “advanced medicine.” There is no drug, no surgical procedure, and no high-tech procedure that comes even close to the astonishing healing power of natural sunlight.
Reducing the Burden of Disease Through Adequate Intake of Vitamin D3
A presentation at University of California, San DiegoApril 9, 2008
by William B. Grant, Ph.D.
Sunlight, Nutrition, and Health Research CenterSan Francisco, California
www.sunarc.org
I am pleased to acknowledge funding from these organizations:
UV Foundation (McLean, Virginia) www.uvfoundation.org
The Vitamin D Society (Canada) www.vitamindsociety.org
The European Sunlight Associationwww.europeansunlight.eu
Learn the vitamin D-sensitive diseases
Bones, Cancers
Infectious diseases, Autoimmune diseases
Metabolic diseases, Congestive heart failure and muscles
Quantify potential benefits of solving vitamin D deficiency
Disease incidence and mortality rate risk reductions
Economic burden reductions
Vitamin D3(cholecalciferol) is made in the
Skin from 7-dehydrocholesterol from
ultraviolet-B (UVB) and a thermal process.
Vitamin D3is converted in the liver to 25-hydroxyvitamin D3(calcidiol
Calcidiolis converted in the kidney and other organs to 1,25-dihydroxyvitamin D3(calcitriol).
Types of evidence used to link risk-modifying factors to disease outcomes:
Ecological studies: populations, diseases and risks delimited geographically
Observational studies: case-control, cohort studies
Meta-analyses of several observational studies
Randomized controlled trials
Laboratory studies can identify mechanisms
Bones and Fracture Risk Reduction
Vitamin D increases the absorption of calcium.
Vitamin D regulates parathyroid hormone (PTH) levels and serum calcium levels. If calcidiollevels are low and PTH levels are high, calcium will be taken from the bones, and may end up in the arterial walls.
Vitamin D supplementation improves neuromuscular or neuroprotectivefunction.
This is a simple way how vitamins D works your immune system is stabilized so it makes your immune system
Repair its own body
Vitamin D 5000 IU £18.75 for 250 caplets you take one a day
John Steeples
Cure Your Self
07883589036
Vitamin D proven far better than vaccines at preventing influenza infections
Natural News) If scientists discovered something that worked better than vaccines at preventing influenza, you’d think they would jump all over it, right?
After all, isn’t the point to protect children and adults from influenza?
A clinical trial led by Mitsuyoshi Urashima and conducted by the Division of Molecular Epidemiology in the the Department of Pediatrics at the Jikei University School of Medicine Minato-ku in Tokyo found that vitamin D was extremely effective at halting influenza infections in children. The trial appears in the March, 2010 issue of the American Journal of Clinical Nutrition (Am J Clin Nutr (March 10, 2010). doi:10.3945/ajcn.2009.29094)
The results are from a randomized, double-blind, placebo-controlled study involving 334 children, half of which were given 1200 IUs per day of vitamin D3. In other words, this was a “rigorous” scientific study meeting the gold standard of scientific evidence.
In the study, while 31 of 167 children in the placebo group contracted influenza over the four month duration of the study, only 18 of 168 children in the vitamin D group did. This means vitamin D was responsible for an absolute reduction of nearly 8 percent.
Flu vaccines, according to the latest scientific evidence, achieve a 1 percent reduction in influenza symptoms (http://www.naturalnews.com/029641_v…).
This means vitamin D appears to be 800% more effective than vaccines at preventing influenza infections in children.
To further support this, what really needs to be done is a clinical trial directly comparing vitamin D supplements to influenza vaccines with four total groups:
Group #1 receives a vitamin D placebo
Group #2 receives real vitamin D (2,000 IUs per day)
Group #3 receives an influenza vaccine injection
Group #4 receives an inert injection
Groups 1 and 2 should be randomized and double blind while groups 3 and 4 should also be randomized and double blind. The results would reveal the comparative effectiveness of vitamin D versus influenza vaccines.
Unfortunately, such a trial will never be conducted because vaccine pushers already know this trial would show their vaccines to be all but useless. So they won’t subject vaccines to any real science that compares it to vitamin D.
Vitamin D also significantly reduced asthma in children
Getting back to the study, another fascinating result from the trial is that if you remove those children from the study who were already being given vitamin D by their parents, so that you are only looking at children who started out with no vitamin D supplementation before the trial began, the results look even better as vitamin D reduced relative infection risk by nearly two-thirds.
More than six out of ten children who would have normally been infected with influenza, in other words, were protected by vitamin D supplementation.
Also revealed in the study: vitamin D strongly suppressed symptoms of asthma. In children with a previous asthma diagnosis, 12 of those receiving no vitamin D experienced asthma attacks. But in the vitamin D group, only 2 children did.
While this subset sample size is small, it does offer yet more evidence that vitamin D prevents asthma attacks in children, and this entirely consistent with the previous evidence on vitamin D which shows it to be a powerful nutrient for preventing asthma.
Vaccine pushers aren’t followers of real science
Now, given that vitamin D3 shows such a powerful effect in preventing influenza — with 800% increased efficacy over vaccines — shouldn’t CDC officials, doctors and health authorities be rushing to recommend vitamin D before flu season arrives?
Of course they should. But they won’t. Because for them, it’s not about actually preventing influenza and it never has been. The vaccine pushing camp is primarily interested in using influenza as an excuse to vaccinate more people regardless of whether such vaccines are useful (or safe).
Even if vitamin D offered 100% protection against all influenza infections, they still wouldn’t recommend it.
Why? Because they flatly don’t believe in nutrition! It runs counter to their med school programming which says that nutrients are useless and only drugs, vaccines and surgery count as real medicine.
The vaccine pushers, you see, aren’t followers of real science. You could publish a hundred studies proving how vitamin D is many times more effective than vaccines and they still would never recommend it.
They are promoters of medical dogma rather than real solutions for patients. They promote vaccines because… well… that’s what they’ve always promoted, and that’s what their colleagues promote. And how could so many smart people be wrong, anyway?
But that’s the history of science: A whole bunch of really smart people turn out to be wrong on a regular basis. That’s usually how science advances, by the way: A new idea challenges an old assumption, and after all the defenders of the old (wrong) idea die off, science manages to inch its way forward against the hoots and heckles of a determined dogmatic resistance.
This attitude is blatantly reflected in a quote from Dr John Oxford, a professor of virology at Queen Mary School of Medicine in London, whose reaction to this study was: “This is a timely study. It will be noticed by scientists. It fits in with the seasonal pattern of flu. There is an increasing background of solid science that makes the vitamin D story credible. But this study needs to be replicated. If it is confirmed we might think of giving vitamin D at the same time as we vaccinate.” (http://www.timesonline.co.uk/tol/ne…)
Did you notice his concluding remark? He wasn’t even considering the idea that vitamin D might replace vaccines. Rather, he’s assuming vitamin D only has value if given together with vaccines!
You see this in the cancer industry, too, with anti-cancer herbs and nutrients. Any time an anti-cancer nutrient gains some press (which isn’t very often), the cancer doctor will say things like, “Well, this might be useful to give to a patient after chemotherapy…” but never as a replacement for chemo, you see.
Many mainstream doctors and medical scientists are simply incapable of thinking outside the very limiting boxes into which their brains have been shoved through years of de-education in medical schools. When they see evidence contrary to what they’ve been taught, they foolishly dismiss it.
“The fact that an opinion has been widely held is no evidence whatever that it is not utterly absurd; indeed in view of the silliness of the majority of mankind, a widespread belief is more likely to be foolish than sensible.” – Bertrand Russell
Medical journals as guardians of ignorance
Medical journals largely function not as beacons of scientific truth but as defenders of pseudoscientific dogma. To have your paper published in most journals, your paper must meet the expectations and beliefs of that journal’s editor. Thus, the advancement of scientific knowledge reflected in each journal is limited to the current beliefs of just one person — the editor of that journal.
Truly pioneering research that challenges the status quo is almost always rejected. Only papers that confirm the presently-held beliefs of the journal’s editorial staff are accepted for publication. This is one reason why medical science, in particular, advances so slowly.
Studies that show vitamin D to be more effective than vaccines will rarely see the light of day in the scientific community. It is to the great credit of the American Journal of Clinical Nutrition, in fact, that it accepted the publication of this paper by Mitsuyoshi Urashima. Most medical journals wouldn’t dare touch it because it questions status quo beliefs about vaccines and influenza.
Medical journals, you see, are largely funded by the pharmaceutical industry. And Big Pharma doesn’t want to see any studies lending credibility to vitamins, regardless of their scientific merit. Even if vitamin D could save America billions of dollars in reduced health care costs (which it can, actually), they don’t want vitamin D to receive any scientific backing whatsoever because drug companies can’t patent vitamin D. It’s readily available to everyone for mere pennies a day.
In time, it will be recognized as superior to vaccines for seasonal flu, but for now, we must all suffer under the foolish propaganda of an industry that has abandoned science and now worships a needle.
Diseases and conditions cause by vitamin D deficiency:
- Osteoporosis is commonly caused by a lack of vitamin D, which greatly impairs calcium absorption.
- Sufficient vitamin D prevents prostate cancer, breast cancer, ovarian cancer, depression, colon cancer and schizophrenia.
- “Rickets” is the name of a bone-wasting disease caused by vitamin D deficiency.
- Vitamin D deficiency may exacerbate type 2 diabetes and impair insulin production in the pancreas.
- Obesity impairs vitamin D utilization in the body, meaning obese people need twice as much vitamin D.
- Vitamin D is used around the world to treat Psoriasis.
- Vitamin D deficiency causes schizophrenia.
- Seasonal Affective Disorder is caused by a melatonin imbalance initiated by lack of exposure to sunlight.
- Chronic vitamin D deficiency is often misdiagnosed as fibromyalgia because its symptoms are so similar: muscle weakness, aches and pains.
- Your risk of developing serious diseases like diabetes and cancer is reduced 50% – 80% through simple, sensible exposure to natural sunlight 2-3 times each week.
- Infants who receive vitamin D supplementation (2000 units daily) have an 80% reduced risk of developing type 1 diabetes over the next twenty years.
Shocking Vitamin D deficiency statistics:
- 32% of doctors and med school students are vitamin D deficient.
- 40% of the U.S. population is vitamin D deficient.
- 42% of African American women of childbearing age are deficient in vitamin D.
- 48% of young girls (9-11 years old) are vitamin D deficient.
- Up to 60% of all hospital patients are vitamin D deficient.
- 76% of pregnant mothers are severely vitamin D deficient, causing widespread vitamin D deficiencies in their unborn children, which predisposes them to type 1 diabetes, arthritis, multiple sclerosis and schizophrenia later in life. 81% of the children born to these mothers were deficient.
- Up to 80% of nursing home patients are vitamin D deficient.
What you can do:
Sensible exposure to natural sunlight is the simplest, easiest and yet one of the most important strategies for improving your health. I urge you to read the book, “The UV Advantage” by Dr. Michael Holick to get the full story on natural sunlight. You can find this book at most local bookstores or through BN.com, Amazon.com, etc. Note: This is not a paid endorsement or an affiliate link. I recommend it because of its great importance in preventing chronic disease and enhancing health without drugs or surgery.
This may be the single most important book on health you ever read.
If more people understood this information, we could drastically reduce the rates of chronic disease in this country and around the world. Sunlight exposure is truly one of the most powerful healing therapies in the world, far surpassing the best efforts of today’s so-called “advanced medicine.” There is no drug, no surgical procedure, and no high-tech procedure that comes even close to the astonishing healing power of natural sunlight.
Diseases and conditions cause by vitamin D deficiency:
* Osteoporosis is commonly caused by a lack of vitamin D, which greatly impairs calcium absorption.
* Sufficient vitamin D prevents prostate cancer, breast cancer, ovarian cancer, depression, colon cancer and schizophrenia.
* “Rickets” is the name of a bone-wasting disease caused by vitamin D deficiency.
* Vitamin D deficiency may exacerbate type 2 diabetes and impair insulin production in the pancreas.
* Obesity impairs vitamin D utilization in the body, meaning obese people need twice as much vitamin D.
* Vitamin D is used around the world to treat Psoriasis.
* Vitamin D deficiency causes schizophrenia.
* Seasonal Affective Disorder is caused by a melatonin imbalance initiated by lack of exposure to sunlight.
* Chronic vitamin D deficiency is often misdiagnosed as fibromyalgia because its symptoms are so similar: muscle weakness, aches and pains.
* Your risk of developing serious diseases like diabetes and cancer is reduced 50% – 80% through simple, sensible exposure to natural sunlight 2-3 times each week.
* Infants who receive vitamin D supplementation (2000 units daily) have an 80% reduced risk of developing type 1 diabetes over the next twenty years.
Shocking Vitamin D deficiency statistics:
* 32% of doctors and med school students are vitamin D deficient.
* 40% of the U.S. population is vitamin D deficient.
* 42% of African American women of childbearing age are deficient in vitamin D.
* 48% of young girls (9-11 years old) are vitamin D deficient.
* Up to 60% of all hospital patients are vitamin D deficient.
* 76% of pregnant mothers are severely vitamin D deficient, causing widespread vitamin Ddeficiencies in their unborn children, which predisposes them to type 1 diabetes, arthritis, multiple sclerosis and schizophrenia later in life. 81% of the children born to these mothers were deficient.
* Up to 80% of nursing home patients are vitamin D deficient.
What you can do:
Sensible exposure to natural sunlight is the simplest, easiest and yet one of the most important strategies for improving your health. I urge you to read the book, “The UV Advantage” by Dr. Michael Holick to get the full story on natural sunlight. You can find this book at most local bookstores or through BN.com, Amazon.com, etc. Note: This is not a paid endorsement or an affiliate link. I recommend it because of its great importance in preventing chronic disease and enhancing health without drugs or surgery.
This may be the single most important book on health you ever read.
If more people understood this information, we could drastically reduce the rates of chronic disease in this country and around the world. Sunlight exposure is truly one of the most powerful healing therapies in the world, far surpassing the best efforts of today’s so-called “advanced medicine.” There is no drug, no surgical procedure, and no high-tech procedure that comes even close to the astonishing healing power of natural sunlight.
Reducing the Burden of Disease Through Adequate Intake of Vitamin D3
A presentation at University of California, San DiegoApril 9, 2008
by William B. Grant, Ph.D.
Sunlight, Nutrition, and Health Research CenterSan Francisco, California
www.sunarc.org
I am pleased to acknowledge funding from these organizations:
UV Foundation (McLean, Virginia) www.uvfoundation.org
The Vitamin D Society (Canada) www.vitamindsociety.org
The European Sunlight Associationwww.europeansunlight.eu
Learn the vitamin D-sensitive diseases
Bones, Cancers
Infectious diseases, Autoimmune diseases
Metabolic diseases, Congestive heart failure and muscles
Quantify potential benefits of solving vitamin D deficiency
Disease incidence and mortality rate risk reductions
Economic burden reductions
Vitamin D3(cholecalciferol) is made in the
skin from 7-dehydrocholesterol from
ultraviolet-B (UVB) and a thermal process.
Vitamin D3is converted in the liver to 25-hydroxyvitamin D3(calcidiol
Calcidiolis converted in the kidney and other organs to 1,25-dihydroxyvitamin D3(calcitriol).
Types of evidence used to link risk-modifying factors to disease outcomes:
Ecological studies: populations, diseases and risks delimited geographically
Observational studies: case-control, cohort studies
Meta-analyses of several observational studies
Randomized controlled trials
Laboratory studies can identify mechanisms
Bones and Fracture Risk Reduction
Vitamin D increases the absorption of calcium.
Vitamin D regulates parathyroid hormone (PTH) levels and serum calcium levels. If calcidiollevels are low and PTH levels are high, calcium will be taken from the bones, and may end up in the arterial walls.
Vitamin D supplementation improves neuromuscular or neuroprotectivefunction.1
1Dhesi JK, et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004 Nov;33(6):589-95.
Bones –Meta-analysis
A vitamin D dose of 700 to 800 IU/d reduced the relative risk (RR) of hip fracture by 26% (pooled RR, 0.74; 95% CI: 0.61-0.88) and any nonvertebralfracture by 23% vscalcium or placebo.
No significant benefit was observed for RCTs with 400 IU/d vitamin D.
Bischoff-Ferrari HA, Willett WC, Wong JB, GiovannucciE, Dietrich T, Dawson-Hughes B. JAMA. 2005 May 11;293(18):2257-64.
Cancer Risk Modifying Factors
There are a number of factors that modify the risk of cancer.
They can often be included in studies by means of indices.
Examples include air pollution, diet, smoking, alcohol consumption, ethnic heritage, and urban/rural residence.
15 Vitamin D-Sensitive Cancers
Vitamin D-sensitive cancers with strong support after accounting for other factors:
Gastrointestinal: Colon, esophageal, gallbladder, gastric, pancreatic, rectal, small intestinal
Urogenital: Bladder, kidney, prostate
Female: Breast, endometrial, ovarian
Blood: Hodgkin’s lymphoma, non-Hodgkin’s lymphoma
U.S. Vitamin D-Sensitive Cancer Deaths
Digestive system118,000
Breast41,000
Genital system51,000
Urinary system27,000
Lymphoma20,000
Total257,000 (46% of all cancer deaths in the U.S. in 2007)
JemalA, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66.
Randomized Controlled Trial
Recent prospective study of vitamin D3and calcium and cancer risk post-menopausal women in Nebraska1
1100 IU of vitamin D3and/or 1400 mg of calcium per day, or a placebo.
Serum calcidiollevels rose from 71.8 nmol/L (28.7 ng/mL) to 96.0 nmol/L (38.4 ng/mL)
The all-cancer incidence for women over the age of 55 years at time of enrollment was reduced by 77% between the ends of the first and fourth years of the study.
1. LappeJM, Travers-Gustafson D, Davies KM, ReckerRR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J ClinNutr2007 Jun; 85(6): 1586-91.
Seasonal Survival in Norway
Cancer Survival with Respect to Season of Diagnosis in Norway1(mortality rate relative risk in southeast Norway vs. midwestwinter for 36 months)
Prostate cancer: 0.76 (0.73-0.79)*
Breast cancer: 0.75 (0.72-0.79)*
Colon cancer:0.79 (0.76-0.82)*
Hodgkin’s lymphoma:0.85 (0.74-0.98)
indicates statistically significant result
1.PorojnicuAC, DahlbackA, Moan J. Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. Adv Exp Med Biol. 2008;624:43-54.
Vitamin D, Cancer Survival: Implications
These findings strongly suggest that for many types of cancer, vitamin D is more important in the latter stages than in the earlier stages.
The mechanisms likely to be involved later are reduction in angiogenesis and metastasis.
However, other mechanisms are also involved in reducing cancer incidence, such as controlling cell differentiation and apoptosis and improving immune system function.
Vitamin D and Cancer Disparities
Two papers reported that differences in solar UVB and vitamin D can explain a good part of the cancer disparities between black and white Americans
Ecological study: Solar UVB was inversely correlated with mortality rates for breast, colon, esophageal, gastric and rectal cancers.
[Grant, J National Med Assoc, 2006]
Cohort study: Black men were at higher risk of total cancer incidence [relative risk (RR), 1.32; (95% CI), 1.08-1.61; P = 0.007] and mortality (RR, 1.89; 95% CI, 1.40-2.56; P < 0.0001), especially digestive system cancer mortality.
[Giovannucci, Cancer EpidemiolBiomarkers Prevent, 2006]
Infectious Diseases
Calcitriolinduces production of human cathelicidin, LL-37, a polypetidewith modest antimicrobial and potent antiendotoxinactivities.1
There is strong evidence that LL-37 can fight bacterial infections.
There is weaker but growing evidence that LL-37 can fight viral infections.
Mookherjee N, RehaumeLM, Hancock RE. Cathelicidinsand functional analogues as antisepsis molecules. Expert OpinTherTargets. 2007 Aug;11(8):993-1004.
Vitamin D and Infectious Diseases: Summary of Evidence of Benefit
Bacterial diseases
Pneumonia
Porphyromonasgingivalis(periodontal disease)
Septicemia
Tuberculosis
Viral diseases, respiratory system
Influenza (seasonal)
Respiratory syncytialvirus (bronchitis)
Rhinovirus (common cold
Autoimmune Diseases
The strongest evidence for a beneficial effect of vitamin D in reducing the risk of autoimmune diseases is for multiple sclerosis (MS) and type 1 diabetes mellitus.
For MS, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D and cytokine expression.
CantornaMT, Mahon BD. D-hormone and the immune system. J RheumatolSuppl. 2005 Sep;76:11-20.
CantornaMT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. ProgBiophysMol Biol. 2006 Sep;92(1):60-4.
Vitamin D and Multiple Sclerosis
A nested case-control study among more than 7 million US military personnel.1
The OR for the highest quintile, corresponding to calcidiollevels higher than 99.1 nmol/L, was 0.38 (95% CI, 0.19-0.75; P = 0.006).
The inverse relation with multiple sclerosis risk was particularly strong for caldidiollevels measured before age 20 years.
1Munger KL, Levin LI, Hollis BW, Howard NS, AscherioA. JAMA. 2006 Dec 20;296(23):2832-8.
Metabolic Diseases
Metabolic diseases include cardiovascular diseases, coronary heart disease, type 2 diabetes, hypertension, stroke, etc.
There is growing observational evidence that vitamin D reduces the risk of metabolic diseases.
However, randomized controlled trials have not been reported yet.
Coronary Heart Disease
There was a graded increase in cardiovascular risk across categories of calcidiol, with multivariable-adjusted hazard ratios of 1.53 (95% CI: 1.00 to 2.36) for levels 10 to < 15 ng/mLand 1.80 (95% CI: 1.05 to 3.08) for levels < 10 ng/mL(P for linear trend=0.01).
Wang TJ, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008 Jan 29;117(4):503-11.
CHD –Vitamin D Mechanisms
Reduces blood pressure.
Reduces risk of infection.
Increases insulin sensitivity.
Reduces circulating osteoprotegerin(a cytokine) levels1
1Gannagé-Yared MH, AzouryM, MansourI, BaddouraR, HalabyG, NaamanR. Effects of a short-term calcium and vitamin D treatment on serum cytokines, bone markers, insulin and lipid concentrations in healthy post-menopausal women. J EndocrinolInvest. 2003 Aug;26(8):748-53.
Vitamin D, Diabetes, Mechanisms
The mechanism of action of vitamin D in type 2 diabetes is thought to be mediated through regulation of plasma calcium levels, which regulate insulin synthesis and secretion, and a direct action on pancreatic beta-cell function.
PalomerX, González-Clemente JM, Blanco-VacaF, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes ObesMetab. 2008 Mar;10(3):185-97.
Congestive Heart Failure (CHF)
CHF results when the heart is no longer able to maintain adequate circulation of blood.
The heart is a muscle.
Risk increases rapidly with increasing age among the elderly.
Those over the age of 60 years produce vitamin D with about one-fourth the efficiency of those under the age of 20 years.
Mortality Rate Data, U.S., 2003
Data are available by sex, race, age for leading causes of death.
The leading causes of death are tabulated in the following tables.
Most of the diseases tabulated are vitamin D sensitive.
The black/white racial disparities are much higher for those aged 55-64 years than 65+ years.
Heron MP, Smith BL. Deaths: leading causes for 2003. NatlVital Stat Rep. 2007 Mar 15;55(10):1-92.
Mortality Rates, Males 55-64 Years
|
Disease |
Black |
White |
Black/White |
|
Cancer |
597 |
385 |
1.55 |
|
Heart |
589 |
312 |
1.89 |
|
Stroke |
114 |
32 |
3.56 |
|
Diabetes |
98 |
38 |
2.58 |
|
Nephritis |
53 |
||
|
Lower respir |
52 |
50 |
1.04 |
|
HIV |
51 |
||
|
Liver |
41 |
31 |
1.32 |
|
Septicemia |
39 |
12 |
3.25 |
|
Disease |
Black |
White |
Black/White |
|
Cancer |
388 |
309 |
1.26 |
|
Heart |
311 |
127 |
2.45 |
|
Diabetes |
79 |
25 |
3.16 |
|
Stroke |
73 |
26 |
2.81 |
|
Nephritis |
37 |
9 |
4.11 |
|
Lower respir. |
33 |
<9 |
>3.67 |
|
Septicemia |
28 |
11 |
2.55 |
|
Hypertension |
21 |
<9 |
>2.33 |
|
Flu, pneum. |
14 |
9 |
1.56 |
Vitamin D and Mortality Rates
We examined the risk of dying from any cause in subjects who participated in randomized trials testing the impact of vitamin D supplementation on any health condition. The study parameters:
18 independent randomized controlled trials
including 57,311 participants
A total of 4777 deaths from any cause occurred
Mean daily vitamin D dose was 528 IU, 5.7 year average.
The summary relative risk for mortality from any cause was 0.93 (95% CI: 0.87-0.99).
AutierP. GandiniS. Arch Intern Med. 2007 Sep 10;167(16):1730-7.
Conclusion
There is enough evidence now to conclude that vitamin D intake or production at the rate of 2000-4000 IU/day, leading to serum calcidiollevels of greater than 40 ng/mL(100 nmol/L) can significantly reduce the burden of both chronic and infectious diseases.
Those with darker skin should take higher vitamin D supplementation
Ode to Sunshine, 1913
Sunshine is a marvelous health-giving and healing power in the world. While sunshine is death to disease-producing agencies, it is life and health to all natural forms of life.
Sit in the sun, recline in the sun, walk on the sunny side of the street, avoid parasols, and ever recognize the sun as a friend and not an enemy, a promoter of health, and a destroyer of disease.
Frederick M. Rossiter, M.D. The Practical Guide to Health. Pacific Press Pub. Assoc., Mountain View, CA. 1913:193-5.
Additional Resources
http://www.sunarc.org/
http://www.vitamindcouncil.org/
http://www.healthresearchforum.org.uk/
http://www.pubmed.gov
At this site you may search over 17 million entries from the world’s health literature dating back to about 1960. Enter key words, authors, and/or dates, then click on the authors’ names to see the abstract.
Harvard Cohort Study, Vitamin D, Cancer